Which two Mexican cartels dominate fentanyl manufacturing and trafficking to the United States?

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The Sinaloa Cartel and Jalisco New Generation Cartel (CJNG) are the two dominant transnational criminal organizations manufacturing and trafficking fentanyl into the U.S. Both operate clandestine laboratories in Mexico, source precursor chemicals primarily from Chinese suppliers, and maintain distribution networks in all 50 U.S. states. The Sinaloa Cartel, particularly the "Los Chapitos" faction, has produced bulk fentanyl since at least 2012. CJNG is described by DEA as "one of the most violent and prolific drug trafficking organizations globally." In 2025, both were designated as Foreign Terrorist Organizations. Trump cited their operations as justification for the WMD designation.

Which two Mexican cartels dominate fentanyl manufacturing and trafficking to the United States?

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